Retatrutide is a triple GIP / GLP-1 / glucagon receptor agonist — the “triple-G” peptide that has become one of the most-studied newer compounds in metabolic research.
What is retatrutide?
Retatrutide (development code LY3437943) is a synthetic peptide studied as a triple agonist — it engages three receptors: GIP, GLP-1, and the glucagon receptor. This third target, glucagon-receptor agonism, is what distinguishes it from dual agonists like tirzepatide and is a major focus of the research interest around it.
The triple-agonist mechanism
Adding glucagon-receptor activity to the incretin pair is studied for its potential influence on energy expenditure and hepatic (liver) metabolism, in addition to the insulin- and appetite-related pathways associated with GLP-1 and GIP. Reported research directions include:
- Energy-expenditure models (the glucagon-receptor contribution).
- Metabolic and glycemic signaling.
- Hepatic-fat research models.
- Appetite and body-composition pathways.
Half-life & forms
Retatrutide has a long research half-life (on the order of six days), supporting once-weekly study schedules. It is supplied lyophilized and is offered here in multiple strengths (5–30 mg) for dose-ranging research.
Retatrutide vs tirzepatide
The natural comparison is with tirzepatide (dual agonist) — the difference is the added glucagon-receptor target. Read the full retatrutide vs tirzepatide comparison, and see GLP-1 & metabolic peptides for the category.
Reconstitution, handling & storage
Retatrutide ships lyophilized and is reconstituted with bacteriostatic water. Use the calculator for exact volumes and the storage guide for stability.
Frequently asked questions
What is retatrutide?
Retatrutide (LY3437943) is a synthetic peptide studied as a triple GIP/GLP-1/glucagon receptor agonist in metabolic and weight-regulation research.
How is retatrutide different from tirzepatide?
Tirzepatide is a dual GIP/GLP-1 agonist; retatrutide adds a third target, the glucagon receptor, which is studied for effects on energy expenditure. See our retatrutide vs tirzepatide comparison.
What is the half-life of retatrutide?
In research models it has a half-life on the order of six days, supporting once-weekly study schedules.
What strengths are available?
Miami Peptide Lab offers retatrutide in multiple strengths (5–30 mg) for dose-ranging research, each lab-tested to 99%+ purity with a COA on request.
Why researchers order from Miami Peptide Lab
- 99%+ purity, lab-tested every lot — a batch-specific COA is available on request.
- Ships from Miami and across the US in 24–48 business hours with tracking, in discreet cold-chain packaging.
- Buy-more-save-more bundle pricing on every vial, plus a reship-or-refund guarantee.
Research use only
All products referenced here are sold strictly for laboratory and research use. They are not intended for human or animal consumption, nor for any therapeutic, diagnostic, or cosmetic use, and must be handled only by qualified professionals in an appropriate research setting.
