What Cagrilintide is
Cagrilintide, development code AM833, is a long-acting analogue of amylin — a 37-residue hormone co-secreted with insulin from pancreatic beta cells. Native human amylin has an awkward property for a research tool: it is strongly amyloidogenic, aggregating into fibrils in solution, which makes it unreliable to work with. Cagrilintide is engineered around that, with substitutions that suppress aggregation and an acylation that extends its half-life.
- CagrilintideLong-acting amylin analogue
- AMY receptors + calcitonin-RCalcitonin receptor with RAMP subunits
- Hindbrain satiety signallingDistinct pathway from GLP-1
- Food-intake endpointsAs measured in preclinical and phase II work
Mechanism as described in published research. Nothing here describes an effect in a person — these compounds are supplied for laboratory research use only.
Amylin receptor signalling
Amylin acts at receptors formed by the calcitonin receptor in complex with receptor activity-modifying proteins (RAMPs). That is an unusual arrangement: the same core receptor produces different pharmacology depending on which RAMP it partners with, so “the amylin receptor” is really a family of assemblies rather than one protein.
Functionally the literature associates amylin signalling with gastric emptying and satiety, through a pathway distinct from the incretin system. That separation is the reason cagrilintide is so frequently studied alongside semaglutide — two independent mechanisms converging on related endpoints allow a study to ask whether the effects are additive, redundant or interfering. The co-formulated blend exists for exactly that design.
What the literature covers
Research areas include:
- Amylin receptor pharmacology — calcitonin receptor/RAMP assemblies and their differing selectivity.
- Combination study design — amylin plus incretin signalling, the most active area.
- Aggregation chemistry — how substitution suppresses the amyloidogenic behaviour of native amylin.
- Gastric emptying and satiety models, alongside the GLP-1 and metabolic peptide class.
Identity and verification
Cagrilintide has the molecular formula C194H312N54O59S2 and a molecular weight of 4409 g/mol (CAS 1415456-99-3). Identifiers matter more here than in most categories: research compounds are sold under trade names, development codes and abbreviations that do not always refer to the same molecule, and a formula is unambiguous where a name is not.
Every lot is tested by an independent laboratory before release. Our certificate library covers the lots currently in stock.
We use two laboratories because purity and identity are different questions. Vanguard Laboratory is ISO/IEC 17025:2017 accredited (A2LA #6377.01.01) and reports chromatographic purity and net quantity with a stated measurement uncertainty. Freedom Diagnostics reports HPLC-UV purity together with LC-MS identity confirmation — the test that catches a substituted compound rather than merely an impure one. A sample can be 99% pure and still be the wrong molecule. How we test →
Handling, reconstitution and storage
Cagrilintide ships lyophilized — freeze-dried to a solid and sealed under vacuum — which is what makes it stable in transit rather than a solution racing a clock. Reconstitute with bacteriostatic water, added slowly down the inside wall of the vial rather than directly onto the powder, then swirled gently. Do not shake: mechanical shear is one of the few things that reliably degrades a peptide in the lab.
Final concentration is a function of the volume added, not of the compound, so the same vial can be prepared at very different concentrations. The reconstitution calculator works out the volume for a target concentration and the reconstitution guide covers the procedure. Store lyophilized vials at −20 °C (−4 °F) protected from light; refrigerate once in solution, and see the storage and stability guide for how long reconstituted material holds.
Common questions
What is cagrilintide?
A long-acting analogue of amylin, a 37-residue hormone co-secreted with insulin. Its development code is AM833. It is engineered to resist the fibril aggregation that makes native amylin impractical to work with, and acylated to extend half-life.
Is cagrilintide a GLP-1 agonist?
No. It acts on amylin receptors — calcitonin receptor/RAMP complexes — which is a separate pathway from the incretin system. That separation is precisely why it is studied alongside GLP-1 agonists rather than instead of them.
Why is cagrilintide studied with semaglutide?
Because the two act through independent mechanisms on related endpoints, so a combined design can test whether effects are additive, redundant or interfering. We stock them co-formulated for that reason.
What does RAMP mean in this context?
Receptor activity-modifying protein. The calcitonin receptor produces different pharmacology depending on which RAMP it partners with, so "the amylin receptor" is a family of assemblies rather than a single protein.
Where to get it
Buy research-grade Cagrilintide — independently tested, certificate published, shipped from Miami with cold-chain packaging. Current pricing for every size is on the price list, and we ship worldwide.
Research use only
Everything referenced here is supplied strictly for laboratory research. These compounds are not drugs, foods, cosmetics or medical devices, are not for human or veterinary use, and are not approved for diagnostic or therapeutic application. Mechanisms are described as studied in preclinical and laboratory research; nothing above describes dosing, treatment or clinical outcome.
